Breaking the Genetic Code

Genetic testing may provide oral health professionals with a new avenue to customize patient care and improve preventive treatments and outcomes, and here’s what dental sales reps need to know.

DNA testing is becoming more readily available and affordable to everyone than ever before — in large part due to the completion of the Human Genome Project in 2003 and the resulting decreased cost of DNA sequencing.1 More than 1,800 genes associated with disease have been discovered.2 Oral health professionals are concerned with three primary diseases of the oral cavity: caries, periodontal diseases, and oral cancer. Microorganisms and the host immune response are etiologic factors in caries and periodontal diseases; however, recent research has demonstrated a genetic susceptibility to these diseases as well.3–6 Research also suggests a genetic relationship to oral cancer.7,8 The potential for clinicians to use genetic research to manage systemic diseases through clinical care, improved delivery of preventive oral care, and clinical practice standards is promising. With the advent of oral-systemic links, the genetic basis of systemic diseases and consumer access to affordable DNA sequencing, the oral health care profession needs to become integrated into the genetic arena. And dental sales reps are wise to understand what this means in terms of the ever-evolving dental practice and its needs.

Genomic research has provided valuable information in predicting disease occurrence and in creating preventive pharmacogenetic approaches to treating systemic genetic disorders. Oncology uses genotyping and pharmacogenetics.9 Epigenetics is another area garnering attention, as environmental and maternal stressors during pregnancy influence changes in gene expression without affecting the nucleotide sequence. Suggestions for future genetic studies involve identifying genes that promote good health and increase disease resistance in the presence of environmental risk factors.10 The rapid evolution of the genetic environment makes it challenging to understand, and this article aims to provide sales reps with a basic understanding of concepts of genetic core skills; how clinicians utilize generational family health histories in disease assessment; genetic testing; and ethical considerations.

geneticGenetic Core Skills

Patients are accessing universal and affordable direct-to-consumer (DTC) genetic testing to research their ancestry and health conditions. In some respects, patients may be more familiar with genetic testing than oral health professionals. The National Coalition for Health Professional Education in Genetics (NCHPEG) recommends that health professionals integrate and understand the interaction of genetic, environmental, and behavioral factors in disease predisposition to provide effective, comprehensive treatment for health issues.11 The NCHPEG advocates specific skills all health professionals should learn as part of genetic assessment and referral,11 as sales reps can inquire as to whether their customers are familiar with such recommendations (Table).

FAMILY HEALTH HISTORY

Oral health professionals perform assessments and consider the oral-systemic connection when treating patients, but they do not typically look at patients through a genetic lens. Patients may present with a history of cardiovascular disease, diabetes, oral-facial changes, and even periodontal diseases, without ever having undergone evaluation for genetic predispositions to health problems. A three-generational family health history is helpful in assessing disease susceptibility, evaluating the social/psychological impact of health-related genetic information, and identifying and referring individuals for genetic counseling.

The U.S. Centers for Disease Control and Prevention (CDC) provides the ability to create a three-generational family health history on its website (cdc.gov/genomics/famhistory/famhist_basics.htm). The resulting illustration created on the CDC website provides clinicians the opportunity to educate their patients about oral-systemic connections, genetic implications, preventive strategies, and oral health care considerations. This provides patients with a better understanding of their health status, oral preventive care, and treatment options. Once the family pedigree has been completed, clinicians may decide that referral for genetic testing or counseling is indicated.


Point of Sale | Entering the Genetic Arena

  • The potential for clinicians to use genetic research to manage systemic diseases through clinical care, improved delivery of preventive oral care, and clinical practice standards is promising.
  • There are two main types of genetic testing: genetic tests available through health care providers and direct-to consumer (DTC) genetic testing.
  • Patients are accessing universal and affordable DTC genetic testing to research their ancestry and health conditions.
  • Genomic research has provided valuable information in predicting disease occurrence and in creating preventive pharmacogenetic approaches to treating systemic genetic disorders. Oncology uses genotyping and pharmacogenetics.9
  • As genetic testing becomes more affordable, consumers can learn more about their propensity toward specific health conditions, be proactive about their care, and share information with health professionals.14 For those diagnosed with a genetic condition, genetic testing can help improve medical management and offer more information about prognosis and preventive treatment.15
  • Salivary diagnostics may provide oral health professionals with a useful tool for determining risk factors for disease and then approaching preventive care with an individualized genetic perspective.

GENETIC TESTING

There are two main types of genetic testing: genetic tests available through health care providers and DTC genetic testing. Genetic testing through health care providers involves both salivary and blood samples that are sent to specialized laboratories for analysis. A health care professional provides interpretation of test results and a referral for genetic counseling, if applicable. The cost for this testing may range from $300 to $3,000, but insurance coverage may be available. With DTC testing, the individual collects his or her own sample and mails it to a company for analysis. Results are sent back to the individual, and in some cases, a counselor or health care provider may be available by phone or online to answer questions. The cost for DTC testing ranges from $100 to $1,000, and it is not covered by insurance.

In 2016, the American College of Medical Genetics and Genomics published a statement recommending that DTC genetic tests should be accredited by the Clinical Laboratory Improvement Amendments (CLIA), which ensures the testing adheres to strict guidelines.12 Not all DTC tests are CLIA accredited.13 The report also provides guidance on genetic counseling for the public, informs consumers that test results can neither confirm nor rule out the possibility of a disease, and discusses protection of privacy issues regarding results. A privacy disclosure should include who will have access to results and whether test results will impact long-term care or disability insurance.12 This is important information that sales reps may discuss further with oral health professionals.

CONSIDERATIONS

As genetic testing becomes more affordable, consumers can learn more about their propensity toward specific health conditions, be proactive about their care, and share information with health professionals.14 For those diagnosed with a genetic condition, genetic testing can help improve medical management and offer more information about prognosis and preventive treatment.15 For some individuals, genetic testing provides a psychosocial benefit of supporting the validity of the diagnosis, as well as offering a support system through genetic disease organizations and counseling.15 Others may find that there are additional costs as further genetic testing may be needed to define genetic links and for the treatment of the disease.16 In the process of undergoing genetic testing, family members may learn unexpected information or incidental results concerning disease susceptibility, or they might learn they are carriers of a genetic disease. These findings may lead to unexpected psychosocial issues that require additional levels of counseling and support.15 Although an individual may present with a genotype for a disease, this does not necessarily mean he or she will actually get the disease.9

genetic

There are also ethical considerations for individuals who use DTC genetic testing. Consumers may be enticed by the prospect of ancestry information, but ill prepared to handle the results. Pre/post-test counseling and professional interpretation of test results may be necessary.13,17 Research indicates that the use of genetic counselors with DTC testing is small — only 1% to 14% of users.18,19 Predictability of the genetic test is also a concern, as some DTC companies are not regulated by the U.S. Food and Drug Administration.13,17

Clinicians and their patients also need to understand that completing genetic testing does not imply that results are completely private. The Genetics Information and Non­discrimination Act (GINA) of 2008 was enacted to prevent genetic testing discrimination in health coverage and employment.20 However, GINA does not cover genetic discrimination for long-term care facilities, life insurance, and disability insurance. GINA also does not prohibit health insurance companies from obtaining and using genetic information to determine insurance premiums. GINA does not apply to veterans, members of the military, individuals using Indian Health Services, and federal employees enrolled in Federal Employees Health Benefits programs20 as these groups have internal protection policies similar to GINA.21

Informed consent is ambiguous when using DTC companies. For example, some companies ask for consumers to sign a brief consent form to participate in their health research programs. If the consumer signs, his or her DNA results can be used in future research and viewed by a third party, with the possibility of producing a genetic commodity for pharmaceutical companies, hospitals, or the government.22

Sales reps can assist their oral health professional clients by educating them on the pitfalls of DTC testing, including the aspect of property rights to excised tissues for commercial use. Historically, the courts have ruled that when surgery is performed, excised biological specimens — such as the appendix, moles, drawn blood, etc — are no longer part of the body. Therefore, the owner does not have rights to the removed tissue, which may become experimental samples for the study of diseases and development of new drugs.23,24 Sometimes cell lines developed from these tissues have great commercial value.23 While it is difficult to refute that human tissue collection is important for genetic and medical research, opponents argue that patients should have control of their tissues and permission should be obtained prior to experimental use.

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FUTURE APPLICATIONS

Recent advances in genetic testing and salivary diagnostic aids have enabled the creation of noninvasive, inexpensive, easy-to-use chairside genetic tests for use in the dental setting. Salivary diagnostic testing may have a future role in diagnosing many conditions, including Sjögren syndrome, cystic fibrosis, cardiovascular disease, diabetes, human immuno­deficiency virus, oral cancer, caries, and periodontal diseases.25 Salivary diagnostic kits designed to detect genetic links to periodontal diseases, as well as the presence of oral humanpapilloma virus, are now available.

Salivary diagnostics may provide oral health professionals with a useful tool for determining risk factors for disease and then approaching preventive care with an individualized genetic perspective. Thinking about genetic etiology when analyzing oral conditions would alter the traditional paradigm on how oral health professionals view the oral cavity and disease manifestations. Adding a genetic alert box and a three-generational family history to the health history form would allow for the incorporation of genetic information in the preventive care provided by oral health professionals.26 With multifactorial diseases — such as cancer, cardiovascular disease, type 2 diabetes, caries, and periodontal diseases — customized treatment plans would include genetic information, environmental factors and exposure, and lifestyle changes. Tobacco use was recently linked to gene-environment interactions.27 This research has the potential to alter tobacco cessation information and programs with patients in the prevention of oral and lung cancers.

Sales reps may encourage their customers to create a handout with genetic resources and genetic counselors for patients who test positive with salivary diagnostics. Informed consent would need to be changed to reflect this type of genetic testing and include GINA guidelines. The development of pharmacogenetics is a promising future as customized drug and adjunctive therapies for oral cancer, periodontal diseases, and caries based on individuals’ genetic profiles would be possible.


Terms to Learn

  • Human Genome Project: Also known as HGP, this international scientific research project sought to determine the sequence of nucleotide base pairs that make up human DNA, and then map those genes from a physical and a functional point of view.
  • Etiologic factors: The underlying cause of a disease.
  • Oral-systemic link: When an oral condition is associated with another health condition; a causative relationship.
  • Systemic diseases: A condition that affects the entire body versus a single area of the body.
  • Direct-to-consumer genetic testing: Increased availability of genetic testing has made way for direct-to-consumer (DTC) genetic testing, which is significantly cheaper than undergoing such testing in a health care practice; not covered by insurance.
  • Genetics Information and Non discrimination Act: Abbreviated as GINA, this act was enacted in 2008 to prevent genetic testing discrimination in health coverage and employment; does not protect consumers against other sharing practices and potential discrimination in specified settings.

CONCLUSION

Genetics is a rapidly advancing field that both consumers and health care professionals are utilizing. Dental sales reps are wise to become educated on this topic, so that they may provide valuable insight and knowledge on this area with their customers. The result is truly comprehensive care, which encourages the union of oral health, genetic, and systemic connections. Genetics in oral health care may provide an additional avenue for customizing preventive care and treatment — and an understanding of it gives sales reps an edge as they aim to provide clients the most current, and informative knowledge on this topic.

BONUS WEB CONTENT

This article is adapted from one previously published in Dimensions of Dental Hygiene.

References

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  2. National Institute of Health RePORT. Human Genome Project. Available at: report.nih.gov/NIHfactsheets/ViewFactSheet.aspx?csid=45. Accessed January 4, 2018.
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  4. Taba M, Scombatti de Souza SL, Mariguela VC. Periodontal disease: A genetic perspective. Braz Oral Res. 2012;26:32–38.
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  6. Carvalho FM, Tinoco EMB, Deeley K, et al. FAM5C contributes to aggressive periodontitis. PLoS One. 2010;5:1–10.
  7. Shailza V, Rahul S, Haque SM, Karunathy S, Subramaniam S. Evaluation of CYP1B1 expression, oxidative stress and phase 2 detoxification enzyme status in oral squamous cell carcinoma patients. J Clin Diagn Res. 2017;11:1–5.
  8. Yu-Fen L, Pei-Zhen Y, Hua-Feng L. Functional polymorphisms in the IL-10 gene with susceptibility to esophageal, nasopharyngeal, and oral cancers. Cancer Biomark. 2016;16:641–651.
  9. Read A, Donnai D. New Clinical Genetics 3. Banbury: United Kingdom; Scion Publishing Ltd; 2015.
  10. Collins FS, Green ED, Guttmacher AE, Guyer MS. A vision for the future of genomics research. Nature. 2003;422:835–847.
  11. National Coalition for Health Professional Education in Genetics. Core Competencies for Health Professionals. Available at: nchpeg.org/ documents/Core_Comps_English_2007.pdf. Accessed January 4, 2018.
  12. American College of Medical Genetics and Genomics Board of Directors. Direct-to-consumer genetic testing: A revised position statement of the American College of Medical Genetics and Genomics. Gent Med. 2016;18:207–208.
  13. Hudson K Javitt G, Burke W, Byers P, ASHG Social Issues Committee. ASHG Statement on Direct-to-Consumer Genetic Testing in the United States. Am J Hum Genet. 2007;81:635–637.
  14. Darst BF, Madlensky L, Schork NJ, Topol EJ, Bloss CS. Characteristics of genomic test consumers who spontaneously share results with their health care provider. Health Commun. 2014;29:105–108.
  15. Cohen J, Hoon A, Floet AMW. Providing family guidance in rapidly shifting sand: Informed consent for genetics testing. Dev Med Child Neurol. 2013;55:766–769.
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  18. Bloss CS, Wineinger NE, Darst BF, Schork NJ, Topol EJ. Impact of direct-to-consumer genomic testing at long term follow-up. J Med Genet. 2013;50:393–400.
  19. Kaufman DJ, Bollinger JM, Dvoskin RL, Scott JA. Risky business: Risk perception and the use of medical services among customers of DTC personal genetic testing. J Genet Couns. 2012;21:413–422.
  20. United States Department of Health and Human Services. Genetics Information and Nondiscrimination Act. Available at: genome.gov/24519851/. Accessed January 4, 2018.
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Featured Image by LIULOLO/ISTOCK/ GETTY IMAGES PLUS

From MENTOR. March 2018;9(3): 14-18.

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